Research progress on eIF3 a and cancer
10.3969/j.issn.1001-1978.2014.04.001
- VernacularTitle:eIF3a与肿瘤的研究进展
- Author:
Hui HE
;
Jiye YIN
;
Honghao ZHOU
;
Zhaoqian LIU
- Publication Type:Journal Article
- Keywords:
eIF3a;
tumor;
cell cycle;
expression;
chemothera-py;
prognosis;
regulatory mechanism
- From:
Chinese Pharmacological Bulletin
2014;(4):445-447,448
- CountryChina
- Language:Chinese
-
Abstract:
Translation is a fundamental step in regulation of gene expression and abnormalities in this process may lead to cancer. In eukaryotic cells, translation of mRNA is mainly regulated by many eukaryotic initiation factors ( eIFs) . EIF3 plays an impor-tant role in translational regulation, cell growth and oncogenesis. The largest subunit of eIF3, eIF3a may play a role as a regulator of mRNAs. The relationship between eIF3a and oncogenesis has been found. Moreover, the eIF3a mRNA is ubiquitously ex-pressed in different cancer cells and can modulate the cell cycle. However, some studies indicate that eIF3a could provide protec-tion against evolution into higher malignancy and reduce the re-sistance to chemotherapy . The patients of high eIF3a expression could get a better prognosis . In fact, the role of eIF3a is still un-clear in cancer cells. EIF3a may be involved in the process of tumor pathophysiology, but its regulatory role is undulatory.
