Improvement in Determination of Diethylene Glycol and Ethylene Glycol in Glycerol
- VernacularTitle:甘油中二甘醇、乙二醇杂质检查方法的改进
- Author:
Tingting ZHANG
;
Tong LI
;
Chen MA
- Publication Type:Journal Article
- Keywords:
Glycerol;
Diethylene glycol;
Ethylene glycol;
Improvement;
GC
- From:
China Pharmacist
2014;(5):743-744,745
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish an improved method for the determination of diethylene glycol and ethylene glycol in glycerol on the basis of the method in Chinese pharmacopoeia (2010 edition). Methods: Glycerol samples were extracted by methanol, and detected by gas chromatography with a flame ionization detector. The column was a DM-624 capillary column(30 m × 0. 53 mm,3μm), and the initial temperature was 80℃ in the first 6min and then risen to 100℃ at the speed of 50℃·min-1, kept for 8min,fi-nally risen to 220℃ at the speed of 10℃·min-1 , kept for 10min. The split injection was used with the split ratio of 100∶1. The in-jection temperature was 250℃ and the detector temperature was 280℃. The flow rate was 6. 0ml·min-1 . Results:The RSD(%) of the method was lower than 5%, and the resolution of all chromatographic peaks met the requirements of the pharmacopoeia. The meth-od was used to analyze the commercial product of glycerol, and the contents of diethylene glycol and ethylene glycol were both less than the specified limits. Conclusion:The method is simple and rapid, and suitable for glycerol impurity inspection.
