Compatible Stability of Sodium Nitroprusside for Injection in Two Infusions
- VernacularTitle:注射用硝普钠在两种输液中的稳定性考察
- Author:
Xiaoming LIN
;
Baohan WEI
;
Yi ZENG
;
Pingyuan WEI
;
Hanqin LIANG
;
Weiqian XIE
;
Mingzhong CHEN
- Publication Type:Journal Article
- Keywords:
Sodium nitroprusside;
HPLC;
Compatibility;
Stability
- From:
China Pharmacist
2014;(4):678-681,682
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the compatible stability of sodium nitroprusside for injection ( SNP) in two kinds of solutions (5% glucose and sodium chloride injections) . Methods:A, B, C and D solution of SNP was respectively prepared according to the concentration of clinical use. The stability of SNP solution was studied in different environment with different storing time, and the as-sessment indices included the appearance, insoluble particles, pH value, ultraviolet-visible absorption spectrum and SNP content. Re-sults:The SNP solutions in 5% glucose and sodium chloride injections were stable in 26 hours in photophobic condition at 20℃ and 35℃. Under an incandescent lamp with or without lightproof, the solutions were very unstable. Conclusion:Both sodium chloride and 5% glucose injections can be used as the solvent for SNP with 26h stability. SNP injections prepared and used in clinics should be pre-served away from light to ensure the safety and effectiveness.
