Pharmacokinetic effect of aspirin on caffeic acid in dengzhanxixin injection
10.3969/j.issn.1001-1978.2014.04.028
- VernacularTitle:阿司匹林对灯盏细辛注射液中咖啡酸的药代动力学影响
- Author:
Guoliang DAI
;
Shijia LIU
;
Changyin LI
;
Lei WU
;
Shitang MA
;
Wenzheng JU
;
Hengshan TAN
- Publication Type:Journal Article
- Keywords:
dengzhanxixin injection;
caffeic acid;
as-pirin;
rat;
plasma;
pharmacokinetics;
LC-MS/MS
- From:
Chinese Pharmacological Bulletin
2014;(4):570-573,574
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the pharmacokinetic effect of aspirin on caffeic acid in dengzhanxixin injec-tion( DI) . Methods Concentration of caffeic acid in rat plasma was detected by LC-MS/MS after rats were given intravenous administration of DI or DI combined with aspirin by gavage. Pharmacokinetic parameters were calculated by DAS 1. 0 pharmacokinetic software. Results In vivo pharmacokinetic models of caffeic acid were two-compartment open models in both the caffeic acid group and the caffeic acid combined with aspirin group. After compatibility, caffeic acid showed a significant increase in T 12β, with a slight decrease in CL. Conclusions Aspirin can reduce metabolic process of caffeic acid in vivo.
