Progress in Pharmacogenomics Research on Immunosuppressive Drugs
- VernacularTitle:免疫抑制药的药物基因组学研究进展
- Author:
Jianxun ZHONG
;
Huawen XIN
- Publication Type:Journal Article
- Keywords:
Immunosuppressive drugs;
Pharmacogenomics;
Gene polymorphism;
CYP;
ABCB1
- From:
China Pharmacist
2014;(5):861-864,865
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppressive drugs used in organ transplantation are highly effective in preventing acute rejection. However,the clinical use of the drugs is complicated by the fact that they display highly variable pharmacokinetics and pharmacodynamics among in-dividual patients. The influence of genetic variation on the interindividual variability in immunosuppressive drug disposition,efficacy and toxicity has been explored in recent years. The review summarized all kinds of immunosuppressants and their relationship with ge-netic polymorphisms,including the SNPs of related enzymes about pharmacokinetics and pharmacodynamics,the SNPs of donor and tar-get site. The review focused on the current situation and progress in the related research areas.
