Establishment of Hyperkalemia Model in Rabbits
- VernacularTitle:家兔高钾血症病理模型的建立
- Author:
Yuan CHEN
;
Weiya ZHU
;
Weijiao LI
;
Li ZHANG
;
Xiaoqing WANG
- Publication Type:Journal Article
- Keywords:
Rabbit;
Hyperkalemia;
Reproduce model;
Electrocardiogram observation
- From:
Journal of Kunming Medical University
2014;(1):32-36,50
- CountryChina
- Language:Chinese
-
Abstract:
Objective According to the special changes of ECG in hyperkalemia animals, explore a method to reproduce a rabbits model for hyperkalemia. Methods Three programs were applied by intravenous drip of 3%KCl to reproduce the hyperkalemia model. In the first program,once the wide and deformed QRS complex occurred, the potassium drip should be stopped immediately. In the second program,the wide and deformed QRS complex was kept for 30 min by adjusting the speed of potassium infusion. In the third program, once low and flat P wave and peaked T wave appeared, immediately adjusted the speed of potassium infusion in order to keep for 30 min. And HR, BP, urine output and serum potassium were monitored simultaneously. Hyperkalemia is defined as serum potassium≥5.1 mol/L. The successful hyperkalemia model should keep serum potassium≥5.1 mol/L after ceasing potassium given 30 min. Results The second and third programs could reproduce a hyperkalemia model successfully. The serum potassium returned to normal within 30 min after stopping potassium given in the first program. Conclusion The method which keep low and flat P wave and peaked T wave for 30 min and keep the wide and deformed QRS complex 30 min could reproduce the hyperkalemia model successfully.
