Expression and Significance of Toll-like receptor-2 and Heme oxygenase-1 in Recurrent Nasal Polyps
- VernacularTitle:Toll样受体-2和血红素加氧酶-1在复发性鼻息肉中的表达及意义
- Author:
Fan ZHANG
;
Jingyu GAO
;
Biao RUAN
- Publication Type:Journal Article
- Keywords:
Toll-like receptor-2;
Heme oxygenase-1;
Recurrent nasal polyps
- From:
Journal of Kunming Medical University
2014;(2):44-47,66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of TLR-2 and HO-1 in recurrent nasal polyps,and to discuss the relationship between the expression and the recurrence of nasal polyps. Methods The immune protein imprinting technology was used to detect the protein expression of TLR-2 and HO-1 in 20 cases of recurrent nasal polyps,20 cases of nasal polyps and 20 cases of normal mucosal tissue in control group, and the relationship between the two proteins were analyzed. Results Expression levels of TLR-2 and HO-1 in the tissues of the recurrent nasal polyps had statistically significant difference with nasal polyps group ( <0.05) . Expression levels of TLR-2 and HO-1 in the tissues of the nasal polyps had statistically significant difference with normal nasal mucosa tissues ( <0.05) .The expression of TLR-2 and HO-1 had significant correlation in each group ( <0.05) .Conclusion TLR-2 and HO-1 plays an important role in the recurrence mechanism of nasal polyps, and both of them may be as objective indicators for postoperative follow-up of patients with recurrent nasal polyps and judging the recurrent trend.
