Synergistic effect of Huang Lian Jie Du Decoction on sodium valproate in epileptic rats induced by lithium chloride-pilocarpine
10.3969/j.issn.1671-8348.2014.06.019
- VernacularTitle:黄连解毒汤对丙戊酸钠在氯化锂-匹罗卡品致癫痫大鼠体内的减毒增效作用
- Author:
Haiyun ZHOU
;
Pinjun LI
;
Qiang WANG
;
Mingchun HUANG
;
Yao LIU
- Publication Type:Journal Article
- Keywords:
sodium valproate;
Huang Lian Jie Du Decoction;
hepatotoxicity
- From:
Chongqing Medicine
2014;(6):689-691,695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate synergistic effect of Huang Lian Jie Du decoction (HLT) on sodium valproate(SVA) in epi-leptic rats by epileptic rats induced by lithium chloride-pilocarpine .Methods Epileptic rats were induced by intraperitoneal injection of lithium chloride and pilocarpine .The synergistic anti-epilepsy effect of HLT and SVA was investigated .The level of ALT ,AST , SVA in serum ,GSH-Px and MDA were determined at the end of a 4 week adminstration .Then the ultrastructure alteration of the liver were also observed by transmission electon microscope .Results The adminstration of SVA together with HLT can reduce be-havior of epileptic rats .Significant decrease in the level of ALT ,AST ,and SVA in serum of rats and noticeable increases in the ac-tivity of GSH-Px were observed in the co-administered groups compared with administere SVA alone group(P<0 .01) .At the same time ,light microscopic study indicates rats in co-administered SVA and high-dose HLT group has intacthepatic histology .Conclu-sion HLT could has synergistic anti-epileptic effect and relieve the hepatotoxoicity of SVA when co-administered .
