The expression of Blimp1 mRNA in peripheral blood mononuclear cells of tuberculosis patients
10.3969/j.issn.1671-8348.2014.09.002
- VernacularTitle:转录因子Blim p1在结核病患者外周血单个核细胞中的表达研究
- Author:
Mingxu ZHANG
;
Wanyan CHEN
;
Xiaohong XIE
;
Xiaokang ZHANG
;
Fake LI
;
Ming CHEN
;
Shaoli DENG
- Publication Type:Journal Article
- Keywords:
transcription factors;
tuberculosis,pulmonary;
gene expression
- From:
Chongqing Medicine
2014;(9):1029-1030,1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze Blimp1 expression difference in the latent and active of tuberculosis patients and the healthy , and assess possibility of as the new tuberculosis diagnostics molecules .Methods 60 patients with active TB (active tuberculosis group) ,50 participants with latent(latent tuberculosis group) ,and 50 healthy people(control group) were enrolled separately .Using fluorescence quantitative polymerase chain reaction were used to determin Blimp 1 mRNA expression in the peripheral blood mono-nuclear cells .Results Blimp1 mRNA expression level of the active tuberculosis group was 15 .35 times than the control group ,and 2 .21 times than the latent tuberculosis group ,the difference was statistically significant (P<0 .05) .Conclusion Blimp1 gene proba-bly plays a role in the immune response to tuberculosis .it provides new ideas for the laboratory diagnosis of tuberculosis and new clues for further exploring the pathogenesis mechanism of tuberculosis .
