Research on the clinical value of urinary NTx,serum BAP and BMD in patients with bone metastasis from malignant tumors
10.3969/j.issn.1671-8348.2014.09.013
- VernacularTitle:uNTx 、sBAP、BMD检测在恶性肿瘤骨转移中的诊断价值
- Author:
Lingyun WANG
;
Xiaofang LIU
;
Tao DU
;
Lijia LI
;
Xiaoyan HU
;
Lei LIU
;
Ming LI
- Publication Type:Journal Article
- Keywords:
neoplasms metastasis;
bone neoplasms;
urinary pyridinoline cross-linked N-telopeptides of Type Ⅰ collagen;
serum bone specific alkaline phosphates;
bone density
- From:
Chongqing Medicine
2014;(9):1061-1062,1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the variance and clinical significance of urinary pyridinoline cross-linked N-telopeptides of Type Ⅰ collagen(uNTx) ,serum bone specific alkaline phosphates(sBAP) and Bone mineral density(BMD) in patients with bone metastasis malignant tumors .Methods The levels of 53 case patients′,who with bone metastasis ,uNTx and sBAP were measured by ELISA and BMD was detected by dual energy x-ray absorptiometer .40 cases of non-bone metastasis people was assayed .Results The levels of all bone markers in patients with bone metastasis was significantly higher than in the patients without bone metas-tasis(P<0 .05) .The levels of the two biomarkers showed a positive correlation with the number of metastatic loci in bone (P<0 .05) .But there was not significantly different between the levels of uNTx or sBAP with the severity of the bone pain (P>0 .05) . BMD decreased in patients with bone metastasis group ,but it was no difference in the non-bone metastasis(P>0 .05) .Conclusion uNTx and sBAP are helpful for early diagnosis and prevention of patients with bone metastasis from malignant tumors .Patients with malignant gumor is often accompanied by a decrease in BMD .
