The efficacy and safety of different simvastatin doses on hyperlipidemia in the elderly

VernacularTitle:辛伐他汀剂量对老年高脂血症患者疗效与安全性的影响
Author: Fuchun LIU ; Guowei WANG ; Hang SONG ; Hao ZHANG ; Jun GAO
Publication Type:Journal Article
Keywords: hyperlipidemia; elderly; simvastatin; treatment outcome
From: Chongqing Medicine 2014;(9):1088-1089,1092
CountryChina
Language:Chinese
Abstract: Objective To study the efficacy and safety of different simvastatin doses on hyperlipidemia in the elderly .Methods 120 patients with hyperlipidemia were randomly divided into two groups ,60 cases in each group ,patients were given simvastatin 10 mg/d(10 mg/d group) or 20 mg/d(20 mg/d group) .Data were collected before and after treatment ,including total cholesterol (TC) ,three acyl glycerin (TG) ,low density lipoprotein cholesterol (LDL-C) ,high density lipoprotein cholesterol (HDL-C) ,treat-ment efficacy and adverse reactions events .Results 3 month after treatment ,TC ,TG ,LDL-C and HDL-C were better than before treatment in both groups(P<0 .05);and the curative effect in 20 mg/d group was better than 10 mg/d group(P<0 .05) .There was no significant difference in incidence of adverse reactions events between the two groups (P>0 .05) .Conclusion 20 mg/d simvasta-tin is better than 10 mg/d simvastatin in efficacy of elderly patients with hyperlipidemia ,and offers a safe and reliable treatment .