The expression of N-cadherin and vimentin in rectum adenocarcinoma and their clinical value
10.3969/j.issn.1671-8348.2014.08.014
- VernacularTitle:N-cadherin和vim entin在直肠腺癌中的表达及其临床意义
- Author:
Junjun ZHANG
;
Yi GUO
- Publication Type:Journal Article
- Keywords:
mucins;
vimentin;
rectum neoplasms;
adenocarcinoma;
neoplasms metastasis
- From:
Chongqing Medicine
2014;(8):935-936,940
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of neuronal cadherin (N-cadherin) and vimentin in primary rectum adenocarci-noma tissues and their clinical value .Methods 58 cases of primary rectum adenocarcinoma tissues after surgical resection and con-firmed by pathology ,and normal rectum tissues that at lest 5 cm away from the tumor were selected .The immunohistochemical SP method was used to detect the expression of N-cadherin and vimentin and analyzed their correlation .Results In rectum adenocarci-noma tissues ,the positive expression rate of N-cadherin and vimentin[53 .4% (31/58) ,46 .6% (27/58)]were significantly higher than those of in normal rectum mucosa tissues[3 .4% (2/58) ,1 .7% (1/58)] ,(P<0 .01) .The expressions of N-cadherin and vimen-tin were positively correlated with the depth of cancer invasion ,lymph node metastasis ,distant metastasis and tumor-node-metasta-sis(TNM) stage(P<0 .05) ,but without correlated with the tumor cell differentiation(P>0 .05) .Conclusion N-cadherin and vim-entin have close relationships with metastasis of rectum adenocarcinoma ,to detect the expressions of N-cadherin and vimentin is of a effective method to judge the metastasis and prognosis of rectum adenocarcinoma .
