New evidences of α7nAChR participating in 100 Hz EA regulating NK cells activity

VernacularTitle:α7尼古丁受体介导100Hz电针调节自然杀伤细胞活性的实验研究
Author: Zhiping HU ; Zhihua HUANG ; Cheng HUANG
Publication Type:Journal Article
Keywords: electroacupuncture; natural killer cell activity; α7nAChR
From: Chongqing Medicine 2014;(5):582-583,586
CountryChina
Language:Chinese
Abstract: Objective On the basis of previous experiments ,we try further to seek the new evidences of α7nAChR participating in 100 Hz electroacupuncture (EA ) regulating natural killer (NK ) cells activity .Methods α7nAChR antibody and the specificα7nAChR antagonist α-bungarotoxin (α-Bgt) were used to study the effect of α7nAChR on NK cell activity in 100 Hz EA mice .Re-sults Compared with 100 Hz EA group ,100 Hz EA plus α7nAChR-Ab group showed a significant enhanced in NK cell activity (P<0 .05) .100 Hz EA treated with 1 .5 or 3 .0 μg α-Bgt groups had higher NK cell activity than 100 Hz EA group(P<0 .01) . Conclusion α7nAChR is involved in 100 Hz EA modulation for immune function ,which provide the theoretical and practical basis for further clarifying and expanding the clinical application of EA .