Correlation between plasma mitochondrial coupling factor-6 level in coronary circulation and coronary stenotic degree in CHD patients
10.3969/j.issn.1008-0074.2014.02
- VernacularTitle:冠心病患者冠脉循环中血浆线粒体偶联因子-6含量与冠脉狭窄程度的相关性
- Author:
Jian MA
;
Qiang CHENG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Coronary circulation;
Mitochondrial coupling factor 6
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(2):117-122
- CountryChina
- Language:English
-
Abstract:
Objective: To study correlation between plasma mitochondrial coupling factor-6 (MCF-6) level in coronary circulation and coronary stenotic degree in CHD patients. Methods: A total of 64 CHD patients were selected as CHD group, and they were further divided into single-vessel group, double-vessel group and multi-vessel coronary disease group; another 20 cases with normal coronary artery were enrolled as normal control group. Radioimmunoassay method was used to measure plasma MCF-6 concentration in peripheral, coronary sinus and aortic root in each group. Multivariant linear gradual regressive analysis was used to analyze above-mentioned correlation. Results: Compared with normal control group, there was significant increase in plasma MCF-6 concentration in peripheral, aortic root and coronary sinus in CHD patients (P<0.05 all) ；compared with aortic root and peripheral plasma, there was significant increase in MCF-6 concentration [(348±48) pg/ml vs. (340±51) pg/ml vs. (402±56) pg/ml, P<0.01 all] in coronary sinus of CHD group；Compared with single-vessel group, double-vessel group, there were increase in MCF-6 concentration in multi-vessel coronary disease group (P<0.05～0.01); Multivariant linear gradual regressive analysis indicated that Gensini score was significant positively correlated with plasma MCF-6 concentrations in coronary sinus and aortic root (r=0.650, P<0.01; r=0.711, P<0.01). Conclusion: Mitochondrial coupling factor-6 participates in the pathophysiological process of coronary heart disease, which may be an important vasoactive substance during development of coronary heart disease.
- Full text:P020140704395475238641.doc
