Influence of sleep deprivation on serum interleukin-1β level in rats with coronary atherosclerosis
10.3969/j.issn.1008-0074.2014.01
- VernacularTitle:睡眠剥夺对冠状动脉粥样硬化大鼠血清白介素-1β水平的影响
- Author:
Li TAN
;
Qi HUANG
;
Demei LI
;
Lingling CHEN
;
Yuxin ZHANG
;
Zhixiao WANG
- Publication Type:Journal Article
- Keywords:
Coronary arteriosclerosis;
Interleukin-1;
Sleep deprivation;
Rat
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(1):1-5
- CountryChina
- Language:English
-
Abstract:
Objective: To explore influence of sleep deprivation (SDP) on serum interleukin-1β (IL-1β) level in rats with coronary atherosclerosis (CAS). Methods: A total of 96 healthy SD rats were randomly and equally divided into normal control group, CAS group, SDP group and SDP + CAS group according to number table; rats in CAS group and SDP + CAS group were fed with high cholesterol diet to establish CAS animal model; SDP group and SDP + CAS group received SDP through small platform with water environment. Radioimmunoassay was used to measure serum concentration of IL-1β; and serum concentrations of total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured respectively; above indexes were compared among four groups. Results: (1) Compared with serum IL-1β level of normal control group, there were significant increase in SDP group, CAS group and SDP + CAS group[(13.33±3.20) ng/L vs. (14.40±4.41) ng/L vs. (22.21±5.94) ng/L vs. (30.17±7.45) ng/L] (P<0.05～<0.01); (2) Levels of TC, TG and LDL-C in CAS group and SDP + CAS group were significantly higher, level of HDL were significantly less than those of normal control group and SDP group (P<0.05～<0.01), levels of above indexes in SDP + CAS group were significantly higher or less than those of CAS group (P<0.05 all). Conclusion: Sleep deprivation can significantly heighten serum interleukin-1β level and total cholesterol, triglyceride, low density lipoprotein-cholesterol levels, decrease HDL level in rats with coronary atherosclerosis or sleep deprivation.
- Full text:P020140704376300546001.doc
