Clinicopathologic changes of gigantomastia
10.3760/cma.j.issn.1673-4203.2013.10.006
- VernacularTitle:巨乳症的临床病理研究
- Author:
Na WANG
;
Yong LI
;
Yingjun SU
;
Chen XU
;
Ming LEI
- Publication Type:Journal Article
- Keywords:
Gigantomastia;
Breast hypertrophy;
Receptors,estrogen;
Estrogen-related receptor gamma;
Pathological conditions,signs and symptonis;
Treatment outcome
- From:
International Journal of Surgery
2013;40(10):665-668,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical and pathologic changes in gigantomast.Methods Tissue sections were prepared from 180 cases of breast hypertrophy and 45 cases of normal breast tissues.The morphological changes and the expression and localization of ERRγwere evaluated on the HE and immunohistochemistry stained sections between hypertrophy and normal breast tissues.Results Compared with normal breast,hypertrophic breast showed expended ducts and obvious hyperplasia of the duct epithelial papillary.Hypertrophic breast tissues demonstrated strong expression of ERR-γ in ducts and lobules.Conclusions Upregulated expression of ERRγ is identified in hypertrophic breast tissues that may associate with the development of gigantomastia.
