Study of the activities of ChAT and CHE in patients with non-dementia vascular cognitive impairment

VernacularTitle:非痴呆性血管性认知功能障碍患者ChAT和CHE活性变化及其临床意义
Author: Fan WANG ; Jian LIU
Publication Type:Journal Article
Keywords: cognition disorders; choline acetyltransferase; cholinesterase
From: Chongqing Medicine 2013;(28):3342-3343,3346
CountryChina
Language:Chinese
Abstract: Objective To study of the activities of choline acetyltransferase (ChAT ) and cholinesterase(CHE) in non-dementia vascular cognitive impairment (VCIND)patients ,and explore its mechanism .Methods Sixty-one patients with VCIND were select-ed as the research group (which accord with Rockwood diagnostic criteria for cognitive dysfunction but not meet the NINDS-ARI-IEN diagnostic criteria for vascular dementia)and 75 healthy people in the same period as the control group .Venous blood was col-lected in the early morning and serum was separated in both of the two groups .The activities of ChAT and CHE were detected by spectrophotometric method .Results The activity of ChAT in the research group(120 .94 ± 23 .93) U/mL was increased significant-ly than the control group(64 .88 ± 12 .23) U/mL(P<0 .01) ,while there was no significant difference in CHE activity between the two groups(P>0 .05) .Conclusion The increased activity of ChAT in VCIND patient and enhance the synthesis of acetylcholine , which may be a compensatory mechanism of VCIND .