The influence of early mechanical ventilation and perfluorocarbons gasification inhalation on inflammatory factor levels in patients with severe pancreatitis
10.3969/j.issn.1671-8348.2013.30.003
- VernacularTitle:早期机械通气及全氟化碳气化吸入对重症胰腺炎患者炎性因子水平影响
- Author:
Hong XIE
;
Yuan LI
- Publication Type:Journal Article
- Keywords:
early mechanical ventilation;
perfluorocarbons;
pancreatitis;
respiratory distress syndrome,adult
- From:
Chongqing Medicine
2013;(30):3599-3600,3603
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect by early mechanical ventilation and perfluorocarbons gasification inhala-tion on patients with severe acute pancreatitis (SAP) complicated with acute respiratory distress syndrome (ARDS) .Methods 34 cases of SAP and ARDS patients accepted early mechanical ventilation and vaporization of perfluorocarbon inhalation therapy (ob-servation group) ,and 34 patients received mechanical ventilation for early treatment alone (control group) ,The efficacy ,oxygenation index(PaO2/FiO2 ) and inflammatory cytokines IL-1 ,6 ,8 ,and TNF-a level of two groups were compared .Results The total effi-ciency of the observation group was 94 .12% ,which was significantly higher than the control group that was 76 .47% (P<0 .05) . After treatment ,the arterial oxygen saturation (SaO2 ) ,arterial oxygen pressure (PaO2 ) ,PaO2/FiO2 of the observation group in-creased significantly ,and higher than the control group(P<0 .05) .After treatment ,IL-1 ,6 ,8 ,TNF-αof the observation group were significantly lower than the control group(P<0 .05) .Conclusion The treatment of early mechanical ventilation with perfluorocar-bon inhalation gasification could control the inflammation in patients with SAP complicated with AROS ,which could improve the cure rate .
