An Experimental Study on the Dynamic Expression of Oct-4B in Rats with Pulpitis by Immunohistochemistry
- VernacularTitle:在大鼠牙髓炎中的八聚体结合转录因子4B免疫组化研究
- Author:
Weidong LAN
;
Yingchun DONG
- Publication Type:Journal Article
- Keywords:
Oct-4B;
Pulpitis;
Rat
- From:
Journal of Kunming Medical University
2013;(10):10-13,21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a model of rat endotoxic pulpitis induced by Lipopolysaccharide (LPS);to study the dynamic expression and location of Oct-4B in rat pulpitis model at different time;To evaluate the role of Oct-4B on pulp injury and reparation in rat endotoxic pulpitis. Method The slides were made and the dynamic expression and location of Oct-4B was examined by immunohistochemistry. Results Oct-4B was moderately positive in the pulp fibroblasts and odontoblasts in 2 weeks. After 2 weeks, it was still positive in odontoblasts and fibroblasts. Up to 3 weeks, it was weakly positive in odontoblasts and fibroblasts. Conclusion Oct-4B is dynamically expressed in the rats with pulpitis, and may play an important role in the incidence,development and recovery of pulpitis.
