The Clinical Effect of Recombinant Human Epidermal Growth Factor in Treatment of Chronic Tympanic Membrane Perforation
- VernacularTitle:重组人表皮生长因子治疗慢性鼓膜穿孔对内耳功能的影响
- Author:
Yan LIN
;
Fang YIN
;
Jiang CHEN
;
Zhong BAI
;
Shixi LIU
;
Jingjing ZHANG
- Publication Type:Journal Article
- Keywords:
Recombinant human epidermal growth factor;
Tympanic membrane;
Perforation;
Chronic;
Inner ear
- From:
Journal of Kunming Medical University
2013;(9):102-104,109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of recombinant human epidermal growth factor (rhEGF) on the treatment of chronic tympanic membrane perforation and the function of inner ear. Methods From 2005 to 2008, the outpatients were randomly divided into three groups (A:control group, B:kangfuxin group, C:rhEGF group) . The patients were also divided into three groups (small, medium and large) . The hearing level and the function of inner ear in three groups were compared. Results The hearing level of rhEGF group was 4.5, which was significantly than that of other groups (7.3 and 9.4 respectively, <0.05) . There was no significant difference in the function of inner ear among the three groups ( >0.05) . Conclusion rhEGF can decrease the healing time significantly and increase the healing rates in the treatment of chronic tympanic membrane perforation, and it has no obvious adverse effects on the inner ear.
