Effect Observation and Preliminery Mechanism Exploration of Shengji Corium Elephatis Mastic in Treating Chronic Refractory Skin Ulcer
10.3969/j.issn.1005-5304.2013.11.005
- VernacularTitle:生肌象皮膏治疗慢性难愈性溃疡临床疗效及初步机制
- Author:
Chaojun ZHU
;
Zhaohui ZHANG
;
Jing MA
;
Ying TIAN
;
Junchao SUN
;
Qiang XU
;
Xuya LU
- Publication Type:Journal Article
- Keywords:
chronic refractory skin ulcer;
Shengji corium elephatis mastic;
VEGF
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(11):11-12,27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Shengji corium elephatis mastic in treating chronic refractory skin ulcer, and analyze its preliminary mechanism. Methods Totally 62 patients with chronic refractory skin ulcer in granulation stage were randomly divided into two groups, 32 cases of treatment group were treated with Shengji corium elephatis mastic, and 30 cases of control group were treated with Vaseline gauze. All patients were treated for 4 weeks. The rate of wound healing, wound reduction ratio and wound secretion level of VEGF were observed. Results The cure rate and the total effective rate between the two groups had significant difference (P<0.05). After 2 weeks treatment, the mean wound reduction area of treatment group and control group was 82.31%and 66.32%respectively. After 4 weeks treatment, the mean wound reduction area of treatment group and control group was 90.35%and 78.7%respectively, the difference was statistically significant (P<0.05). After 1, 2 and 3 weeks treatment, the treatment group had significant difference with the control group in wound secretion VEGF level (P<0.05). Conclusion Shengji corium elephatis mastic can promote wound healing of chronic refractory skin ulcer. The possible mechanism is that Shengji corium elephatis mastic promotes the generation of VEGF in wound thus promotes wound repair.
