Optimization of Matrix Formulation of Chuanxiong Rhizoma Cataplasm by Uniform Design and Response Surface Method
10.3969/j.issn.1005-5304.2013.12.024
- VernacularTitle:均匀设计结合效应面法优选川芎凝胶膏剂基质处方
- Author:
Congmin LIU
;
Jie BAI
;
Shouying DU
;
Yang LU
- Publication Type:Journal Article
- Keywords:
uniform design;
response surface method;
cataplasm;
Chuanxiong Rhizoma
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(12):64-66,97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the matrix formulation of the extract of Chuanxiong Rhizoma cataplasm. Methods The optimal proportion of matrix formulation was selected by uniform design and response surface method. The primary adhesion force, lasting adhesion force, peel strength and residuals on the anti-sticking paper were used as test parameters. The optimal ratios of NP-700, glycinate aluminum, glycerin, tartaric acid, the concentration of drug, and the volume of drug were acquired. Results The matrix formulation of the cataplasm was made with NP-700∶glycinate aluminum∶glycerin∶tartaric acid∶concentration of drug∶volume of drug=1.1∶0.08∶7∶0.04∶4∶5. Conclusion Uniform design combined with response surface method can be used for the optimization of the matrix formulation of cataplasm. The optimal matrix prescription has higher drug-loading, with good spreadability, moisture-retention capability and adhesive force.
