Effect of Moldavica Total Flavone on Pulmonary Function in Ovalbumin-induced Bronchial Asthmatic Rats
10.3969/j.issn.1005-5304.2013.12.009
- VernacularTitle:香青兰总黄酮对支气管哮喘大鼠肺功能的影响
- Author:
Xiaolong KANG
;
Mingda YAO
;
Chenghui HE
;
Lili YAN
- Publication Type:Journal Article
- Keywords:
moldavica total flavone;
bronchial asthma;
airway hyperresponsiveness;
Col Ⅲ;
pulmonary function;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(12):24-25,28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of moldavica total flavone on pulmonary function and collagen type Ⅲ in lung tissue of ovalbumin-induced bronchial asthmatic rats. Methods A total of 60 SD rats were randomly divided into control group, model group, dexamethasone group, and moldavica total flavone low, medium and high dose group. Rat asthma model was established by ovalbumin challenge methods except the control group. The control and model group were intragastrically given distilled water, medicine groups were intragastrically given moldavica total flavone and dexamethasone for 30 d, once per day. After the last administration, the pulmonary function and airway responsiveness including breathing frequency (F), minute ventilation (MVb), peak inspiratory flow (PIFb), peak expiratory flow (PEFb) and enhanced pause (Penh) were measured by using non-invasive measurement system (Penh system, Buxco, USA). The collagen type Ⅲ in lung tissue were detected by ELISA. Results The moldavica total flavone at 180 and 360 mg/kg decreased F and Penh (P<0.05, P<0.01), increased MVb, PIFb and PEFb (P<0.05), and decreased collagen type Ⅲ in lung tissue (P<0.05, P<0.01). Conclusion Moldavica total flavone can relieve the airway hyperresponsiveness and remodeling, improve respiratory function of ovalbumin-induced bronchial asthmatic rats.
