Antioxidative Dosage-effect Relationship of Grape Seed Proanthocyanidin Extract
10.3969/j.issn.1005-5304.2013.12.014
- VernacularTitle:葡萄籽提取物原花青素抗氧化作用量效关系研究
- Author:
Suhua XIE
;
Feng YUE
;
Xia CHEN
;
Ran JIN
;
Dan LIU
;
Hantao ZHANG
;
Jinsheng LI
- Publication Type:Journal Article
- Keywords:
grape seed;
proanthocyanidin;
D-galactose;
antioxidation;
dosage-effect relationship;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(12):37-38,39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the antioxidative dosage-effect relationship of grape seed proanthocyanidin extract (GSPE). Methods The mice were randomly divided into seven groups:blank group, model group, 5 mg/kg GSPE group, 15 mg/kg GSPE group, 45 mg/kg GSPE group, 135 mg/kg GSPE group and 405 mg/kg GSPE group. The mice in blank group were dealt with saline solution by intraperitoneal injection, the others were dealt with D-galactose (120 mg/kg) by intraperitoneal injection for seven weeks to make oxidative damage model. Meanwhile, the mice were given corresponding dose of the drug. Subsequently the level of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in the serum were measured to observe the antioxidative dosage-effect relationship of GSPE. Results The 45, 135, 405 mg/kg GSPE group reduced the MDA level, and the 15, 45, 135, 405 mg/kg GSPE group increased the SOD activity. Conclusion GSPE has significant antioxidant activity on mice dealt with D-galactose above the dose of 15 mg/kg, suggesting that the clinical use of GSPE should guarantee a certain dose to play a good antioxidant effect.
