The value of prognosis of NT-proBNP in severe sepsis and septic shock patients
10.3969/j.issn.1671-8348.2013.33.013
- VernacularTitle:血浆N末端脑钠肽前体对严重脓毒症和脓毒症休克患者预后判断的价值
- Author:
Yuanhua LI
;
Xiuchan SONG
;
Yingjing QI
;
Peiyang ZENG
;
Suhua WU
;
Zhijun LAI
;
Shufeng XIE
- Publication Type:Journal Article
- Keywords:
sepsis;
N terminal pro-brain natriuretic peptide;
septic shock;
prognosis
- From:
Chongqing Medicine
2013;(33):4012-4013,4016
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of prognosis of NT-proBNP in severe sepsis and septic shock patients .Methods 70 patients with sepsis admitted to our hospital were divided into general sepsis group (n=23) ,severe sepsis group(n=28) and sep-tic shock group(n=19) according to the severity of the disease ,the plasma NT-proBNP ,lactic acid ,C-reactive protein were meas-ured within 1 h after admission ,and calculated the 24 h acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) .Results (1) Plasma NT-proBNP concentration ,lactic acid ,CRP and APACHE Ⅱ score in severe sepsis group ,septic shock group was sig-nificantly higher than that of general sepsis group(P< 0 .05);Plasma NT-proBNP concentration ,CRP and APACHE Ⅱ score in septic shock group was significantly higher than severe sepsis group (P<0 .05) .(2)70 cases of patients with sepsis with 15 cases died and 55 cases survived .Plasma NT-proBNP concentration ,lactate ,CRP and APACHEⅡscore of death patients was significantly higher than the survival patients(P<0 .01) .(3) Plasma NT-proBNP concentration at the time of sepsis patients admitted to hospi-tal with positively correlated to APACHE Ⅱscores(r=0 .528 ,P<0 .01) .Conclusion The plasma NT-proBNP is closely related to the prognosis of patients with sepsis ,early detection of plasma concentration of NT-proBNP helps to evaluate the prognosis of pa-tients w ith sepsis .
