Expressions of Caveolin-1 and PCNA in esophageal squamous cell carcinoma and its biological significance in 150 cases
10.3969/j.issn.1671-8348.2013.32.014
- VernacularTitle:150例食管鳞癌Caveolin-1和PCNA蛋白的表达及其生物学意义
- Author:
Xing ZHAO
;
Chunjing JIAO
;
Chunhui LI
;
Chanchan HU
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
caveolin-1;
proliferating cellnu clear antigen;
immunohistochemistry
- From:
Chongqing Medicine
2013;(32):3889-3890,3893
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression levels and significance of Caveolin-1 and proliferating cell nuclear antigen (PC-NA) in esophageal squamous cell carcinoma .Methods Immunohistochemical SP method was used to detect the expression levels of caveolin-1 and PCNA in 150 cases of esophageal squamous cell carcinoma and 35 cases of normal esophageal squamous cell . Results The expressions of Caveolin-1 in esophageal carcinoma was significantly higher than in normal esophageal mucosa (P<0 .05) ,caveolin-1 was related to lymph node metastasis ;The expressions of PCNA in esophageal carcinoma was significantly higher than in normal esophageal mucosa(P<0 .05) ,PCNA was related to age ,lymph node metastasis and tumor size .The expression of Caveolin-1 was positively correlated with PCNA (r=0 .266 ,P<0 .05) .Conclusion Caveolin-1 and PCNA overexpression might be related to the occurrence ,development and metastasis of esophageal squamous cell carcinomas .
