Effect of Tirofiban on high sensitivity C-reactive protein and hypoxia inducible factor-1αin Patients with Non-ST-elevation acute coronary syndromes
- VernacularTitle:替罗非班对非ST段抬高型急性冠脉综合征患者HIF-1α和hs-CRP的影响
- Author:
Jinglin CHENG
;
Jun WAN
- Publication Type:Journal Article
- Keywords:
tirofiban;
hypoxia inducible factor-1α;
high sensitivity C-reactive protein;
acute coronary syndromes
- From:
Acta Universitatis Medicinalis Anhui
2013;(12):1542-1543,1544
- CountryChina
- Language:Chinese
-
Abstract:
80 NSTE-ACS patients were randomly divided into 2 groups: the control group and the therapy group (40 cases in each group). The therapy group was treated with Tirofiban besides the conventional treatment which received by the control group. The level of HIF-1α and hs-CRP was detected immediately, 12, 24, 48 h,and 7 d after hospitalization. The HIF-1αlevel of both group increased in the first 12 hours and then decreased gradually to the baseline in 7 days. The hs-CRP level of both group increased gradually and reached its peak after 24 h after hospitalization, then decreased. Compared with the control group, the level of HIF-1α and hs-CRP decreased sig-nificantly at 12, 24, 48 h and 7 d after hospitalization in the therapy group.
