Study of serum IL-32 and chemokine CXCL13 in patients with rheumatoid arthritis
- VernacularTitle:类风湿关节炎患者血清中白介素-32及趋化因子CXCL13水平的检测和临床意义
- Author:
Mingming ZHANG
;
Rui ZHANG
;
Jianhua XU
- Publication Type:Journal Article
- Keywords:
arthritis,rheumatoid;
chemokine;
cell factor
- From:
Acta Universitatis Medicinalis Anhui
2013;(12):1512-1514,1515
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the serum levels of IL-32 and chemokine CXCL13 in patients with rheumatoid arthritis and explore their clinical value. Methods The serum levels of IL-32 and chemokine CXCL13 were meas-ured by ELISA methods in 102 patients with RA and 50 healthy controls;analyzed the correlation among the IL-32, chemokine CXCL13 and the clinical data, inflammation maker of RA, such as X-ray stage, the bone destruction, the number of tender joints, the number of swollen joints, DAS28,ESR,CRP,CCP,RF,TNF-α,IL-6, etc. Results The serum levels of IL-32 and chemokine CXCL13 were significantly higher in RA patients than that in healthy controls(P<0.05). Moreover,the serum levels of IL-32 and chemokine CXCL13 those patients who had bone de-struction were higher than those with no or mild bone destructions(P<0.05);there was a positive correlation be-tween IL-32, chemokine CXCL13 and X-ray stage, the bone destruction, DAS28, ESR,CRP,CCP,TNF-α,IL-6. Especially, there was a positive correlation between IL-32 and chemokine CXCL13 (r=0.509,P=0.000). How-ever, there was no relationship with the number of swollen joints, tender joints, and RF. Conclusion The serum levels of IL-32 and chemokine CXCL13 were increased significantly,which was closly related with the disease activ-ity and inflammation maker. The results indicate that the abnormality of IL-32 and chemokine CXCL13 may be use-ful for the evaluation of disease activity and monitoring the progress of the disease.
