Analysis on the situation of angiotensin-converting enzyme gene polymorphism in military service officers of Jinan theater

VernacularTitle:济南战区陆勤干部血管紧张素转换酶基因多态性分析
Author: Jing WANG ; Mingmin DI ; Dongmei ZHANG ; Lihua YU
Publication Type:Journal Article
Keywords: the military service officer; peptidyl-dipeptidase A; polymorphism,genetic; gene
From: Chongqing Medicine 2013;(36):4385-4386,4389
CountryChina
Language:Chinese
Abstract: Objective To investigate and analysis the situation of angiotensin-converting enzyme (ACE) gene polymorphism in military service officers of Jinan theater .Methods Roche Cycler480II fluorescence quantitative PCR analyzer was used to detected ACE genotype .Meanwhile ,some samples were randomly analyzed by agarose gel electrophoresis .Results ACE DD genotype ac-counted for 23 .3% in the military service officers of Jinan theater cadres ,ID type accounted for 43 .2% ,II type accounted for 33 .5% ,D and I allele frequencies were 0 .44 and 0 .56 ,respectively ;type II ACE gene frequency was highest in female cadres ,while frequency of ID type was highest in male cadres ,the difference was statistically significant between two groups (P< 0 .05);the difference of allele frequency between men and women was not statistically significant (P>0 .05) .Conclusion ACE gene polymor-phism with type II and Iallele were dominant in the military service officers of Jinan theater cadres ;ACE gene polymorphism survey is important for early detection and timely prevention of certain related diseases .