General Pharmacological Study of Aloe’s Whole-leaf Freeze-dried Powder
10.3969/j.issn.1005-5304.2014.01.017
- VernacularTitle:芦荟全叶冻干粉的一般药理学实验研究
- Author:
Hairun YANG
;
Huicong CHEN
;
Xiaoguang ZHU
;
Guangping ZHANG
;
Jianying ZHAI
;
Siyu ZHANG
;
Wei JIANG
;
Jinsheng LI
;
Suhua XIE
- Publication Type:Journal Article
- Keywords:
Aloe's whole-leaf freeze-dried powder;
Chinese drug pharmacology;
mice;
dogs
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(1):54-57,61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the general pharmacological effects of Aloe's whole-leaf freeze-dried powder (AWFD), and observe its influence on cardiovascular system, nervous system and respiratory system of laboratory animals, so as to offer an experimental basis for clinical application. Methods Forty-eight mice were randomized into blank control group, high dosage group, medium dosage group and low dosage group of AWFD (12 mice for each group). AWFD high, medium and low dosage groups were treated by intragastric at the dose of 12.20, 3.90, 0.65 g/(kg?d), blank control group was treated by equal volume of sterilized distilled water. After three days, general behavior, spontaneous activity, coordinated movement, sleep situation induced by sodium pentobarbital in subthreshold dose and suprathreshold dose were observed. Twenty-four beagle were randomized into blank control group, high dosage group, medium dosage group and low dosage group of AWFD (6 beagles for each group). AWFD high, medium and low dosage groups were treated by duodenum at the dose of 6.10, 3.41, 0.71 g/(kg?d), blank control group was treated by equal volume of sterilized distilled water. The influence on blood pressure, heart rate, electrocardiogram, breathing flow and frequency in anesthetic dogs were observed. Results Three dosages of AWFD had no obvious influence on spontaneous activity and coordinated movement in mice, and had no evidently influence on sleep number and duration, but the high dosage group of AWFD had influence on sleep latency (P<0.01). AWFD had no impact on blood pressure, heart rate, electrocardiogram, breathing flow and frequency in anesthetic dogs. Conclusion AWFD has no evident effects on cardiovascular system and respiratory system in laboratory animal, however, the impact on the central nervous system remains to be further verified.
