Study on application of the Revised International Prognostic Scoring System in myelodysplastic syndrome

VernacularTitle:IPSS-R 标准在骨髓增生异常综合征中的应用研究
Author: Yanping HU ; Xuan LIU ; Minyu ZHANG ; Fang CHEN ; Nan ZHANG ; Jihong ZHANG
Publication Type:Journal Article
Keywords: myelodysplastic syndrome; cytogenetics; Revised International Prognostic Scoring System
From: Chongqing Medicine 2013;(34):4126-4127,4131
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical and cytogenetic features of myelodysplastic syndrome (MDS) ,and to investigate the application of the International Prognostic Scoring System Revised (IPSS-R) in myelodysplastic syndrome .Methods A retro-spective analysis was conducted on 112 patients diagnosed with MDS on basis of French-American-British(FAB) and World Health Organization(WHO) criterion .Conventional cytogenetics are performed to investigated the cytogenetics changes .Results Karyo-type abnormalities are found in 46(41 .1% ) patients .Cytogenetics subgroups are devided into 5 groups according to IPSS-R criteri-on :very good ,good ,intermediate ,poor ,very poor ,which account for 2 cases(1 .8% ) ,48 cases (42 .9% ) ,41 cases (36 .6% ) ,10 ca-ses (8 .9% ) ,11 cases (9 .8% ) ,with a median survival time(MS) 59 ,36 ,15 ,10 month respectively ,except for very good .Conclusion It is of great guiding significance of IPSS-R criteria for prognostic stratification .