The efficacy and safety analysis of immediately intravesical instillation of same dose variable concentration of pirarubicin for superficial bladder cancer
10.3969/j.issn.1671-8348.2014.01.025
- VernacularTitle:等剂量不同浓度吡柔比星即刻膀胱灌注疗效及安全性分析
- Author:
Ning LIU
;
Bin XIE
;
Shixue LIU
- Publication Type:Journal Article
- Keywords:
intravesical installation;
superficial bladder cancer;
pirarubicin;
drug concentration
- From:
Chongqing Medicine
2014;(1):72-73,76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of intravesical instillation of pirarubicin (T HP) to prevent the post -operative recurrence of superficial bladder cancer with same dose variable concentration .Methods A tota1 of 56 cases of superficial bladder cancer after transurethral resection (TURBT ) were randomly divided into two groups(High concentration group :25 cases , Low concentration group :31 cases) .Infusion dose of THP is 30 mg .The concentration of THP is 1 .0 g/L in H group ,0 .6 g/L in L group .Both groups were installed within 24 hours after operation .Both groups were installed once a week for 8 weeks after the first installation ,then once a month until 1 year after operation .All cases were followed up ,the tumor recurrence time ,recurrence rates and complications were compared .Results All cases except 2 in L group received 6 -30 months follow up ,with an average time of 17 .6 months .In H group ,1 patients recurred during the follow-up period ,with a recurrence rate of 4 .0% and recurrence time of 12 .4 months ,while in L group ,3 cases recurred ,with a recurrence rate of 10 .3% and an average recurrence time of 9 .8 months .Adverse reactions were main1y Urinary irritation symptoms .The difference of recurrence rate and average recurrence time in each group were statistically significant (P< 0 .05) ,while the difference of adverse reactions were not statistically significant (P>0 .05) .Conclusion This study shows that high concentration THP intravesical instillation could effectively reduce the recur-rence rate and delay the recurrence time .Each concentration was well tolerated .
