Correlation Between Diffusion Weighted Imaging, Tumor Cellularity and Expression Level of Hypoxia-inducible Factor-1αin Cerebral Astrocytoma
10.3969/j.issn.1005-5185.2013.12.003
- VernacularTitle:星形细胞瘤MRI扩散加权成像、肿瘤细胞密度与缺氧诱导因子-1α表达水平的相关性
- Author:
Yongpeng CUI
;
Chang SHU
;
Yanbing ZHU
;
Huan WANG
;
Wenzhi YU
- Publication Type:Journal Article
- Keywords:
Astrocytoma;
Diffusion magnetic resonance imaging;
Diffusion weighted imaging;
Apparent diffusion coefficient;
Tumor cells;
Cell count;
Hypoxia-inducible factor-1α
- From:
Chinese Journal of Medical Imaging
2013;(12):891-893,898
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the correlation among diffusion weighted imaging (DWI), tumor Cellularity and hypoxia-inducible factor-1α (HIF-1α) for the high and low grade astrocytoma. Materials and Methods DWI was applied with 33 patients with astrocytoma confirmed by pathology, and ADC value was measured. Tumor Cellularity was measured using Scion Image 4.0.3.2. The expression of HIF-1α was tested using immunohistochemisty. Results Mean ADC value was higher in the low grade astrocytoma than that in the high grade astrocytoma (t=7.300, P<0.001). The tumor Cellularity was higher in the high grade astrocytoma than that in the low grade astrocytoma (t=-3.845, P<0.01). HIF-1αexpression could be demonstrated in the low grade [(20.08±10.01)%] and high grade [(47.91±19.03)%] astrocytoma. The negative correlation was demonstrated between ADC value and HIF-1αand tumor Cellularity (r=-0.756,-0.617;P<0.001). The positive correlation was demonstrated between HIF-1αand tumor Cellularity (r=0.622, P<0.001). Conclusion ADC value can be used to discriminate the low and high grade astrocytoma, and the role of HIF-1αshould be further to study with enlarged sample.
