Correlation between levels of liver fibrosis and liver fibrosis biochemical pa-rameters of advanced schistosomiasis patients
- VernacularTitle:晚期血吸虫病肝纤维化程度与生化指标的相关性
- Author:
Yiming WU
;
Xiaofei XU
;
Wenlin WU
;
Wanxin WU
;
Shuxing GAO
;
Wenjun ZHU
- Publication Type:Journal Article
- Keywords:
Advanced schistosomiasis;
Liver fibrosis;
B ultrasound;
Liver biopsy;
Correlation
- From:
Chinese Journal of Schistosomiasis Control
2014;(1):65-66,77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the levels of liver fibrosis and liver fibrosis biochemical parameters of advanced schistosomiasis patients. Methods A total of 48 advanced schistosomiasis patients were investigated and they were examined by the liver biopsy and B ultrasound imaging. At the same time,the liver fibrosis biochemical parameters,including glu-tamine transpeptidase(GGT),alkaline phosphatase(AKP),procollagenⅢ(PC-Ⅲ),collagen typeⅣ(Ⅳ-C),hyaluronic acid (HA)and laminin(LN),were detected. The liver fibrosis levels were classified by the liver biopsy and B ultrasound imaging,re-spectively,and the correlation between the levels of liver fibrosis and liver fibrosis biochemical parameters were analyzed statisti-cally. Results There was no correlation between the liver fibrosis levels classified by the liver biopsy and all the liver fibrosis bio-chemical parameters;there was a weak correlation between the liver fibrosis levels classified by the B ultrasound imaging and GGT,AKP,LN and PC-Ⅲ,respectively;there was a significant correlation between the liver fibrosis levels classified by the B ul-trasound imaging and HA andⅣ-C,respectively. Conclusions B ultrasound examination is a better,noninvasive fibrosis in-spection method. Liver fibrosis biochemical parameters combined with the B ultrasound examination may better reflect the overall condition of liver fibrosis.
