Influence of left-thoracic radiotherapy on heart function and quality of life in patients with breast cancer after breast-conserving surgery
10.3969/j.issn.1008-0074.2013.06
- VernacularTitle:左侧胸部放疗对乳腺癌保乳术患者心功能及生活质量分的影响
- Author:
Fei LONG
;
Xinfeng ZHANG
;
Cong WANG
;
Yang LI
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms;
Radiotherapy;
Ventricular function, left;
Quality of life
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2013;22(6):578-583
- CountryChina
- Language:English
-
Abstract:
Objective: To observe the influence of left-thoracic radiotherapy on heart function and quality of life in patients with breast cancer after breast-conserving surgery. Methods: A total of 35 patients with breast cancer, who recently received breast-conserving surgery and left-thoracic radiotherapy, were continuously selected as radiotherapy group. They received routine echocardiography (ECG), tissue Doppler imaging (TDI) and evaluation of Chinese questionnaire of quality of life in patients with cardiovascular diseases (CQQC) before and after radiotherapy. The results were compared with those of 31 patients (control group), who received radical mastectomy without breast radiotherapy in the same period. Results: There were no significant difference in left heart function indexes by ECG and TDI, all dimensional and total scores of CQQC between two groups before radiotherapy (P>0.05 all). After five-week treatment, compared with evaluation before radiotherapy and control group after treatment, there were significant decrease in E [(0.90±0.32) cm/s vs. (0.90±0.38) cm/s vs. (0.86±0.29) cm/s], E/A [(1.28±0.46) vs. (1.28±0.45) vs. (1.20±0.38)], Em [(10.12±1.93) cm/s vs. (9.95±1.64) cm/s vs. (7.51±1.12) cm/s], Em/Am [(1.25±0.26) vs. (1.24±0.23) vs. (0.90±0.15)] （P<0.05 all）, all dimensional scores （P<0.05～<0.01）and total score [(67.36±7.87) scores vs. (63.75±7.26) scores vs. (52.83±6.40) scores] （P<0.01）of CQQC in radiotherapy group. Conclusion: There are often decrease in left heart function and quality of life in patients with breast cancer undergoing left-thoracic radiotherapy after breast-conserving surgery, so it’s necessary to perform targeted rehabilitative treatment.
- Full text:P020140110385352526991.doc
