Intervention Effect of Xiaotan Hezhong Recipe on Pancreatic Fibrosis and Expression of Related Proteins in Chronic Pancreatitis Rats
10.3969/j.issn.1005-5304.2013.10.012
- VernacularTitle:消痰和中方对慢性胰腺炎大鼠胰腺纤维化形成及相关蛋白表达的干预作用
- Author:
Dan WANG
;
Jianpeng JIAO
;
Pinkang WEI
- Publication Type:Journal Article
- Keywords:
chronic pancreatitis;
Xiaotan Hezhong Recipe;
pancreatic fibrosis;
laminin;
matrix metalloproteinase-1;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(10):32-34,37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Xiaotan Hezhong Recipe on pancreatic fibrosis forming and the expression of related proteins in model rats of chronic pancreatitis. Methods Twenty-four Wistar rats were randomly divided into normal group, model group, pancreatin group and Chinese medicine group (n=6). Rats model were made by DDC solution intraperitoneal injection. Pancreatin group and Chinese medicine group were treated by intragastric administration with pancreatin and Xiaotan Hezhong Recipe, respectively. Body weight of rats was measured regularly. The rats were killed after 4 weeks, with pancreatic pathological detection and laminin, matrix metalloproteinase-1 detection. Results After intraperitoneal injection of DDC solution, pancreatic tissue fibrosis in different degree and inflammatory cell infiltration were found. Chinese medicine group was better than the model group in general conditions, body weight change, pancreatic pathological score and expression of laminin, matrix metalloproteinase-1, the differences were statistically significant (P<0.05). Conclusion Xiaotan Hezhong Recipe can improve chronic pancreatitis rats generally and inhibit pancreatic fibrosis, its mechanism may be related with decreasing laminin expression and increasing the expression of matrix metalloproteinase-1.
