Change of Capillary Pericapillary Cells in Rats with Myocardial Infarction and Effect of Supplementing Qi and Activating Blood Circulation Herbs
10.3969/j.issn.1005-5304.2013.07.015
- VernacularTitle:心肌梗死大鼠毛细血管周细胞变化及益气活血中药对其的影响
- Author:
Kun HUANG
;
Dandan YANG
;
Shuwen GUO
;
Qing SUN
;
Lu ZHANG
;
Xin QI
;
Ting WAN
;
Chenglong ZHENG
- Publication Type:Journal Article
- Keywords:
supplementing qi and activating blood circulation herbs;
myocardial capillary density;
number of pericapillary cells;
myocardial infarction;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(7):38-41,42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of capillary pericapillary cells in rats with myocardial infarction and the influence of supplementing qi and activating blood circulation herbs, and explore its mechanism of improving myocardial perfusion. Methods The rat model was established by ligaturing the left anterior descending coronary artery. On the base of ECG evaluation, successfully modeled rats were randomly divided into the model group, group treated with supplementing qi and activating blood circulation Chinese medicine (activating blood and supplementing qi group), group treated with Perindopril (Perindopril group), group treated with Tongxinluo Capsules (Tongxinluo group). The sham-operation group was taken as the control. There were totally 5 groups. The model group and the sham-operation group were treated with normal saline. The changes of myocardial capillary density (MCD) and number of pericapillary cells on the 7th, 28th day after medicinal administration were observed. Results On the 7th and 28th day, the MCD decreased significantly and the number of capillary pericapillary cells increased significantly in the model group compared with the sham-operation group (P<0.01). The MCD increased significantly in the activating blood and supplementing qi group, Perindopril group and Tongxinluo group compared with the model group (P<0.01). The number of pericapillary cells decreased significantly in the activating blood and supplementing qi group, Perindopril group and Tongxinluo group compared with the model group (P<0.01). Conclusion The supplementing qi and activating blood circulation herbs can improve regional myocardial blood supply by decreasing the number of pericytes and promoting regeneration of capillary.
