Clinical observation on Vinorelbine plus Cisplatin in treatment of advanced metastatic breast cancer
10.3760/cma.j.issn.1008-6706.2013.15.021
- VernacularTitle:国产长春瑞滨联合顺铂治疗晚期乳腺癌的近期疗效观察
- Author:
Youen LIN
;
Xiaofen WANG
;
Chunbing WANG
;
Hongwei XU
;
Jiapeng XING
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Drug therapy;
Vinorelbine;
Cisplatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(15):2290-2292,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficiency and toxicity of Vinorelbine(NVB) combined with Cisplatin (DDP) in the treatment of advanced breast cancer patients resistent to Adriamycin (ADM) or Taxol treatment.Methods 34 patients with 8 cases simplex carcinoma,20 cases infiltrating duct carcinomas,3 cases medullary carcinoma,1 case large sweat gland-like carcinoma and 2 cases scirrhous carcinoma,who were relaped and refractory after ADM or Taxol treatment,were treated with NVB 25mg/m2,DDP 25mg/m2,Ⅳ.Both drugs were given in a 21-days cycle.The efficacy was evaluated every 2 or 3 cycles by using response evaluation criteria in solid tumor.Results 2 cases of 34 assessable patients achieved complete response (CR),18 patients had partial response (PR),8 cases had stable disease(S D),6 cases had progressive disease(PD).The total effective rate was 58.8％ (CR + PR).The medium duration of response and medium survival time were 8.5 months and 18.3 months,respectively.The predominant toxicity was hematological,with grade Ⅲ～ Ⅳ leukopenia occurring in 50.0％ (17/34) patients.Other toxicities were nausea,vomiting,anemia,phlebitis and so on.Conclusion The regimen of NVB combined with DDP is active and well tolerated,with an acceptable price,in treatment of advanced breast patients with refractory and relapsed after ADM or Taxol treatment.
