Quality Standard for Longdan Xiegan Capsule and Longdan Xiegan Soft Capsule
10.3969/j.issn.1005-5304.2013.10.020
- VernacularTitle:龙胆泻肝胶囊及软胶囊质量标准研究
- Author:
Ying LIU
;
Hong LIANG
;
Jin QI
;
Xintong FU
- Publication Type:Journal Article
- Keywords:
Longdan Xiegan Capsule;
Longdan Xiegan Soft Capsule;
gentiopicrin;
geniposide;
baicalin;
TLC;
HPLC
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(10):54-58,59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the quality standards of Longdan Xiegan Capsule and Longdan Xiegan Soft Capsule. Methods Gentianae Radix et Rhizoma, Bupleuri Radix, Scutellariae Radix, Gardeniae Fructus, Alismatis Rhizoma, Angelicae Sinensis Radix, Rehmanniae Radix and Glycyrrhizae Radix et Rhizoma were identified by TLC. Gentiopicrin in Gentianae Radix et Rhizoma, geniposide in Gardeniae Fructus, baicalin in Scutellariae Radix were determined by HPLC. Results The TLC spots developed were clear. Gentiopicrin showed good linear relationship in the range of 0.066 1-0.595 1 mg (r=1.000 0), the average recovery of Capsule was 99.34%(RSD=1.50%), and the average recovery of Soft Capsule was 96.62%(RSD=1.50%). Geniposide showed good linear relationship in the range of 0.076 1-1.369 8 mg (r=0.999 9), the average recovery of Capsule was 101.3% (RSD=1.70%), and the average recovery of Soft Capsule was 100.59%(RSD=0.79%). Baicalin showed good linear relationship in the range of 0.214 4-1.608 mg (r=1.000 0), the average recovery of Capsule was 101.12% (RSD=1.30%), and the average recovery of Soft Capsule was 98.07% (RSD=2.40%). Conclusion The method is simple and reproducible. It can be used to control the quality of Longdan Xiegan Capsule and Longdan Xiegan Soft Capsule.
