Clinical Research on Wenxiao Decoction in Treatment of Carotid Atherosclerostic Plaque
10.3969/j.issn.1005-5304.2013.08.006
- VernacularTitle:稳消方干预颈动脉粥样硬化斑块临床研究
- Author:
Kan HUANG
;
Qingping HUO
;
Yuxin WANG
;
Wenbo PENG
;
Fang LIANG
- Publication Type:Journal Article
- Keywords:
Wenxiao Decoction;
carotid atherosclerostic plaque;
Chinese medicine
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(8):15-17,18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Wenxiao Decoction in treating the patients with carotid atherosclerostic (CAS) plaque and assess the safety. Methods Sixty patients with CAS plaque were randomly allocated to treatment group (33 cases) and control group (27 cases). The control group was given routine therapy, and the treatment group was given Wenxiao Decoction additionally. And they were further divided into half-year treatment group and half-year control group, 1-year treatment group and 1-year control group. Carotid artery color Doppler ultrasound and hepatorenal function were examined before and after treatment. Results Compared with the control groups after therapy, the average numbers of plaques, maximal plaque thickness, Crouse plaque integral were decreased both in 1-year and half-year treatment groups (P<0.05, P<0.01). The plaque stability of 1-year treatment group was better than that of half-year treatment group. The average numbers of plaques, plaques size and Crouse plaque integral increased in control groups after routine therapy (P<0.05, P<0.01). Bilateral common carotid artery diameter, intima-medial thickness (IMT) and hepatorenal function had no statistical difference between before and after treatment both in treatment and control groups (P>0.05). Conclusion Wenxiao Decoction is effective and safe in treatment of CAS plaque, and plaque stability is more obvious with the extension of treatment time.
