Adeno-Associated Virus 2-Mediated Hepatocellular Carcinoma is Very Rare in Korean Patients.
10.3343/alm.2016.36.5.469
- Author:
Kyoung Jin PARK
1
;
Jongan LEE
;
June Hee PARK
;
Jae Won JOH
;
Choon Hyuck David KWON
;
Jong Won KIM
Author Information
1. Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea. kimjw@skku.edu
- Publication Type:Original Article
- Keywords:
Adeno-associated virus 2;
Epidemiology;
Hepatocellular carcinoma;
Korean
- MeSH:
Adult;
Asian Continental Ancestry Group;
Capsid Proteins/genetics;
Carcinoma, Hepatocellular/etiology/*pathology/virology;
DNA, Viral/chemistry/genetics/metabolism;
DNA-Binding Proteins/genetics;
Dependovirus/*genetics/isolation & purification/pathogenicity;
Female;
Humans;
Incidence;
Inverted Repeat Sequences/genetics;
Liver Neoplasms/etiology/*pathology/virology;
Male;
Middle Aged;
Parvoviridae Infections/complications/epidemiology;
Polymerase Chain Reaction;
Republic of Korea;
Sequence Analysis, DNA;
Viral Proteins/genetics
- From:Annals of Laboratory Medicine
2016;36(5):469-474
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The incidence and etiology of hepatocellular carcinoma (HCC) vary widely according to race and geographic regions. The insertional mutagenesis of adeno-associated virus 2 (AAV2) has recently been considered a new viral etiology of HCC. The aim of this study was to investigate the frequency and clinical characteristics of AAV2 in Korean patients with HCC. METHODS: A total of 289 unrelated Korean patients with HCC, including 159 Hepatitis-B-related cases, 16 Hepatitis-C-related cases, and 114 viral serology-negative cases, who underwent surgery at the Samsung Medical Center in Korea from 2009 to 2014 were enrolled in this study. The presence of AAV2 in fresh-frozen tumor tissues was investigated by DNA PCR and Sanger sequencing. The clinical and pathological characteristics of AAV2-associated HCC in these patients were compared with previous findings in French patients. RESULTS: The AAV2 detection rate in Korean patients (2/289) was very low compared with that in French patients (11/193). Similar to the French patients, the Korean patients with AAV2-related HCC showed no signs of liver cirrhosis. The Korean patients were younger than the French patients with the same AAV2-associated HCC; the ages at diagnosis of the two Korean patients were 47 and 39 yr, while the median age of the 11 French patients was 55 yr (range 43-90 yr). CONCLUSIONS: AAV2-associated HCC was very rare in Korean patients with HCC. Despite a limited number of cases, this study is the first to report the clinical characteristics of Korean patients with AAV2-associated HCC. These findings suggest epidemiologic differences in viral hepatocarcinogenesis between Korean and European patients.
