Analysis of clinical impact of factors ulinastatin on myocardial protection

VernacularTitle:乌司他丁心肌保护作用的临床影响因素分析
Author: Zhiquan TANG ; Rong XING ; Yong TAO ; Yin ZHOU
Publication Type:Journal Article
Keywords: myocardial infarction; ulinastatin; echocardiography; creatine kinase isoenzyme
From: Chongqing Medicine 2013;(23):2745-2746,2749
CountryChina
Language:Chinese
Abstract: Objective Toexploreinfluencingfactorsoftheulinastatin(UTI)onmyocardialprotection.Methods 120casesofa-cute myocardial infarction(AMI) patients were given UTI at the base of conventional treatment for heart failure like thrombolysis , resistance to shock .The patients were divided into group A (within 12 hours) and group B (after 12 hours) ,and than each group was divided into subdivision small dose (250 kU) ,medium dose (500 kU) ,large dose (1 000 kU) groups .The patients were re-ceived echocardiogram examination ,determination of left ventricular contraction end-diastolic diameter(LVESD ,LVEDD) testing , left ventricular ejection fraction(LVEF) testing ,each stroke output(SV) ,peak concentration of creatine kinase isoenzyme(CK-MB) after treated for one week .Results Compared with the small dose and after 12 hours groups ,large dose and within 12 hours group caused an increase of cardiac function and density loss of CK-MB peak concentration (P<0 .05) .Conclusion The same cause of myocardial injury ,dose and administration timing will affect the clinical efficacy of UTI .