Effect of Compoud Qingqin Liquids on Renal Function of Uric Acid Nephropathy Rats
10.3969/j.issn.1005-5304.2013.09.011
- VernacularTitle:复方青秦液对尿酸性肾病大鼠肾功能的影响
- Author:
Xuezheng SHANG
;
Weiguo MA
;
Yu BAI
;
Tiesheng FANG
;
Chunyan ZHANG
;
Hui LIU
;
Yan LU
;
Wen GU
;
Yumei XU
;
Ling TANG
;
Fengxian MENG
- Publication Type:Journal Article
- Keywords:
Compoud Qingqin Liquids;
uric acid nephropathy;
renal function;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(9):31-33,36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Compoud Qingqin Liquids on renal function of rat model of uric acid nephropathy, and to discuss its protection of renal function. Methods The rat model was induced by gavaging adenine and feeding yeast. SD rats were randomly divided into control group, model group, positive group, and high-, medium-, low-dose groups of Chinese medicine. Blank control group and model group were daily gavaged with distilled water, positive control group was daily gavaged with allopurinol by 9.33 mg/kg, and high-, medium-, low-dose group of Chinese medicine was daily gavaged with Compound Qinggin Liguids by 3.77, 1.89, 0.09 g/(kg·d) respectively for 6 weeks. General condition of rats were observed, renal pathological changes were observed with light and electron microscope. Urine protein concentration, blood uric acid, blood urea nitrogen, creatinine and kidney weight index were respectively tested before and after treatment. Results There were no significant differences in eating, drinking and body weight between before and after modeling. Compoud Qingqin Liquids can obviously decrease the concentration of urine protein, blood uric acid, serum creatinine, blood urea nitrogen, and kidney weight index (P<0.05) of rats with uric acid nephropathy. Renal tubular epithelial cells atrophy and renal interstitial fibrosis of high-dose group of Chinese medicine were not evident. Conclusion Compoud Qingqin Liquids can protect the rats renal function against uric acid renal injury.
