Effects of Kangshuaiyizhi Capsule on Cholinergic and Monoamine Neurotransmitter in Brain Tissue of Aging Model Rats
10.3969/j.issn.1005-5304.2013.07.013
- VernacularTitle:抗衰益智胶囊对衰老大鼠脑组织胆碱能神经递质及单胺类神经递质的影响
- Author:
Shiduo ZHENG
;
Hairong XV
;
Yongqiang DUAN
;
Jia LIU
;
Xiangdong ZHU
;
Yingxia CHENG
;
Xiaoyi YANG
;
Rong CHENG
- Publication Type:Journal Article
- Keywords:
cholinergic neurotransmitter;
monoamine neurotransmitter;
Kangshuaiyizhi capsule;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(7):33-34,35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Kangshuaiyizhi capsule on ChAT/AchE and NE, DA and 5-HT levels in the brain tissue of aging model rats, and explore its effect of protecting cerebral function. Methods Totally 72 rats were randomly divided into normal group and model group. The subacutely aging model rats were made by injecting D-gal (0.125 g/kg) into abdominal cavity continually, then aging rats were divided by random number table into model group, Naofukang group and Kangshuaiyizhi high-, low-dose group. After intervented with correspongding drugs for 60 days, activity of ChAT and AchE, cerebral cortex NE, DA, and 5-HT levels were detected. Results Activity of AchE was much higher (P<0.05), but level of ChAT, NE, DA and 5-HT in model group were significantly downregulated compared with normal group (P<0.05). After treated with Kangshuaiyizhi capsule, activity of AchE was downregulated, ChAT, NE, DA and 5-HT levels were significantly upregulated (P <0.01, P <0.05). Conclusion Kangshuaiyizhi capsule can regulate cholinergic and monoamine neurotransmitter levels in the brain tissue of aging model rats, and play a very important role in protecting cerebral function.
