Changes of fiver and kidney function and morphology of the renal artery of the metabolic syndrome rats
10.3760/cma.j.issn.1008-6706.2013.20.021
- VernacularTitle:代谢综合征大鼠肝肾功能和肾动脉形态结构的变化
- Author:
Wei HUANG
;
Yumei LUO
;
Xinhong WAN
;
Hongbo GUO
;
Yi TAN
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Renal artery;
Liver function tests;
Kidney function tests;
Rats
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(20):3090-3091,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toinvestigate the changes of liver and kidney function and morphology of the renal artery of the metabolic syndrome (MS) rats.Methods The rats were respectively fed with ordinary or high-fructose diet for 10 weeks,and then took the blood and anatomical observation,to explore the changes of liver and kidney function and morphology of the renal artery of the rats.Results The serum levels of ALT,AST,UA,BUN,CR in the control group and MS group were gradually increased with the feeding time.But those in MS rats were significantly increased than the control rats.MS rats showed dysfunction of liver and kidney,which similar to the clinical MS cases.Compared with the control group,the renal artery of MS rats had the same pathological changes as MS cases,presented with intima uneven thickening and structural disorder,medial smooth muscle cells hyperplasia to intimal,the internal elastic membrane with different degrees of damage and fracture,the film elastic fibers thickening and structural disorder,smooth muscle cell proliferation apparently,medial obvious thickening.Conclusion MS rats have mild dysfunction of liver and kidney and abnormal changes in intima and tunica media of renal artery.
