Influence of isometric exercise training on blood endothelial progenitor cells in patients with coronary total occlusion
10.3969/j.issn.1008-0074.2013.05
- VernacularTitle:等长收缩运动对冠脉完全闭塞患者血内皮祖细胞的影响
- Author:
Song LIN
;
Yinfu LI
;
Yonghong ZHENG
;
Xiao LU
;
Yongxue LI
;
Mingyue XIAO
;
Liang CHEN
;
Yuling MA
- Publication Type:Journal Article
- Keywords:
Exercise therapy;
Coronary artery disease;
Endothelial cells;
Vascular endothelial growth factor
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2013;22(5):429-436
- CountryChina
- Language:English
-
Abstract:
Objective: To investigate influence of isometric exercise (IE) training on number of endothelial progenitor cells (EPCs) and level of vascular endothelial growth factor (VEGF) of circulating blood in patients with coronary chronic total occlusion (CTO). Methods: A total of 20 CTO patients were divided into training group (n=10) and control group (n=10). Both groups received routine medication for three months, training group also received three-month IE training (maximal handgrip was used to induce maximum IE of upper limb muscles, leading to temporary physiological ischemia of skeletal muscle),while control group remained sedentary without exercise training. Flow cytometry was used to measure number of blood EPCs, and enzyme linked immunosorbent assay (ELISA) was used to measure serum concentration of VEGF. Results: Before treatment, the differences of levels of blood EPCs and VEGF between two groups were no significant（P>0.05）. Compared with before treatment, there were significant increase in blood number of EPCs [(0.028±0.009)% vs. (0.044±0.016)%] and VEGF concentration [(65.3±15.1) pg/ml vs. (98.5±17.4)pg/ml] after three-month treatment in training group (P=0.015, P<0.01), and they were significantly higher than those of control group after treatment. Compared with before treatment, there were no significant difference in blood number of EPCs and concentration of VEGF after treatment in control group, P>0.05. The blood numbers of EPCs were positively correlated with VEGF concentration in training group and control group (r=0.727, r=0.785, P<0.05 both). Conclusions: Isometric exercise training can increase blood number of EPCs and VEGF concentration in coronary CTO patients, which may contribute to collateral angiogenesis in remote ischemic myocardium.
- Full text:P020131108346091861653.doc
