Survival analysis of patients with pathologic T2-3N0 squamous cell carcinoma of thoracic esophagus after esophagectomy

VernacularTitle:病理T2～3N0食管癌切除术后患者的生存分析
Author: Dongkun ZHANG ; Xiaodong SU ; Tiehua RONG
Publication Type:Journal Article
Keywords: Esophageal neoplasms; Surgical operation; Prognostic factors
From: Cancer Research and Clinic 2013;(6):375-377,381
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinicopathologic features of patients with pathologic T2-3N0 thoracic esophageal squamous cell carcinoma (ESCC) and correlation to their prognosis.Methods The clinicopathologic data of 422 patients with pathologic T2-3N0 thoracic ESCC,who were treated with surgery were analyzed.Cumulative survival rate was analyzed by the Kaplan-Meier method and compared by Log-rank test.Cox regression model was used for multivariate prognostic analysis.Results The overall 1-,3-and 5-year survival rates were 89.3 ％,63.5 ％ and 52.5 ％,respectively.Univariate analysis revealed that the factors affecting the prognosis included gender (x2 =7.45,P ＜ 0.01),depth of invasion (x2 =7.79,P ＜ 0.01) andtissues differentiation (x2 =15.81,P ＜ 0.01).They were also independent prognostic factors according Cox regression multivariate survival analysis.Conclusion The gender,depth of invasion and differentiation should be independent prognostic factors of pathologic T2-3N0 ESCC.Surgery is still the standard treatment for pathologic T2-3N0 esophageal cancer.