Metabolism of polyunsaturated fatty acid and its relationship with △6 desaturase activity in colorectal cancer
10.3760/cma.j.issn.1006-9801.2013.05.002
- VernacularTitle:结直肠癌多不饱和脂肪酸代谢与△6脱饱和酶关系的研究
- Author:
Kai YANG
;
Wen TIAN
;
Jin DONG
;
Yan DONG
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Fatty acids,polyunsaturated;
Fatty acids ω-6;
Fatty acids ω-3;
△6 desaturase
- From:
Cancer Research and Clinic
2013;(5):293-295,299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study metabolism of polyunsantured fatty acid (PUFA) and to investigate the relationship between different PUFA compositions and △6 desaturase (D6D) activity in colorectal carcinoma (CRC).Methods Fresh frozen malignant CRC tissues were obtained from 61 patients and blood samples were detected in 38 patients.The PUFA composition in these samples was determined by gas-liquid chromatography on a capillary column.The fatty acid product-to-precursor ratios in blood and tissue as estimates of desaturase activity (D6D activity index),and its relationship with the ratios between different PUFA compositions were investigated.Results Metabolism of ω-6 PUFA dominated in PUFA metabolism path.The ratio of ω-6/ω-3 PUFA was 4.89 in blood samples and 10.15 in tissues.The ratio of LA/ALA was 101.92 in blood samples and 86.16 in tissues.The ratio of ω-6/ω-3 LC-PUFA was 2.86 in blood samples and 4.51 in tissues.The D6D activity index in ω-6 PUFA metabolic processes both in tissues (t =1 1.609,P =0.00) and blood samples (t =-9.151,P =0.00) were higher than that in ω-3 PUFA.Conclusion In colorectal carcinoma,the ω-6 PUFA metabolic not only plays an important role in the metabolism of PUFA,but also is more active than the ω-3 PUFA metabolic,and in some way links to the development of tumorigenesis in CRC.
