Clinical value of the plasma IL-6, the ACE level and DVH parameters on the prediction of radiation pneumonitis
10.3760/cma.j.issn.1006-9801.2013.04.012
- VernacularTitle:血浆白细胞介素6、血管紧张素转换酶水平及放射剂量体积直方图参数对放射性肺炎预测的临床价值
- Author:
Zhijun LIAO
;
Renhua HUANG
;
Hedai LIU
;
Qian HUANG
;
Gang DING
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Radiotherapy,computer assisted;
Radiation pneumonitis;
Interleukin-6;
Peptidyl-dipeptidase A;
DVH parameters
- From:
Cancer Research and Clinic
2013;(4):257-259,262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the plasma IL-6,ACE level and DVH parameters radiation pneumonitis,and to evaluate its clinical value on the prediction of radiation pneumonitis.Methods 60 patients with locally advanced non-small cell lung cancer patients with unresectable or unwilling to surgical resection routinely received three-dimensional conformal radiation therapy.Before radiotherapy,radiotherapy beginning 1 week,2 weeks,3 weeks,4 weeks,5 weeks,6 weeks,8 weeks and 12 weeks,enzyme-linked immunosorbent assay (ELISA) was used to detect IL-6 and ACE content.The evaluation of radiation pneumonitis was accordance with the RTOG acute radiation pneumonitis grading standards.The patients with radiation pneumonitis were included in observation group,otherwise as control group.IL-6,ACE and DVH parameters in two groups were analyzed.The DVH parameters includes V20,V20,MLD and NTP.Results Among all the 60 patients,16 cases were diagnosed as radiation pneumonitis,among whom 5 cases occurred in radiotherapy,10 cases occurred within one month after radiotherapy,1 case occurred in two months after radiotherapy,including the 11 cases of grade Ⅱ and the other 5 cases of grade Ⅲ.In the observation group and the control group,expression level of the IL-6 had statistical significance before and after radiotherapy,ACE had significant difference in 2rd,3rd,4th,5th,6th week after radiotherapy (all P ＜ 0.05).V20,V30 and MLD differences were statistically significant between the observation group and control group [(46.2±4.5) ％ vs (30.5±7.5) ％,(37.5±5.6) ％ vs (20.5±5.6) ％,(20.4±2.3) Gy vs (15.5±3.5) Gy,(25.2±8.2) ％ vs (9.9±4.5) ％,all P ＜ 0.05].Conclusion Plasma IL-6,ACE levels,V20,V30,the MLD,and NTP are related to the occurrence of radiation pneumonitis.
