Analysis on the influential factors of radiation pneumonitis after intensity modulated radiotherapy in lung cancer patients

VernacularTitle:经调强适形放疗治疗的肺癌患者发生放射性肺炎的相关因素分析
Author: Xiang HAN ; Yuan YAO ; Lin LU ; Xuezhen MA
Publication Type:Journal Article
Keywords: Lung neoplasms; Radiotherapy,intensity-modulated; Radiation pneumonitis; Dose-volume histogram
From: Cancer Research and Clinic 2013;(4):238-240,244
CountryChina
Language:Chinese
Abstract: Objective To identify the factors related to radiation pneumonia (PR) in lung cancer treated with intensity modulated radiotherapy (IMRT).Methods Data from 163 lung cancer patients treated with IMRT were analyzed with clinical factors and physical parameters related to the dose-volume histogram.The patients were followed for 6 months after radiotherapy.The relationship between survival status and PR was analyzed.Results The incidence rate of over grade 2 patients was 28.22 ％ (46/163).Univariate analysis revealed a significant relationship between many parameters associated with such as the site of lobe (P =0.033),COPD (P =0.020),chemotherapy (P =0.020) and prophylactic using of glucocorticoid and antibiotic (P =0.025).Multilogistic regression analysis showed that V20 in the contralateral site,the V5 of the all lungs and PTVV were independent factors.Conclusion The RP is associated with multiple factors.Individualized treatment plans should be made according to the specific circumstances of patients.